Lion’s Mane Mushroom Supplements and Extracts: The Ultimate Buyer’s Guide

Lion’s mane is an important mushroom in nature-containing bioactive substances that have many beneficial effects on the body, especially the brain, heart, and gut. In nature these substances help breakdown and decompose dead trees and logs.

Frequency Cap’s Lions Mane Extracts

Lion's Mane Mushroom
Lion’s Mane Mushroom



That’s why when you find mushrooms in nature, they are usually growing out of wood. When you look at a Lion’s Mane mushroom you can see where its name comes from as the mushroom itself closely resembles the “mane” on the lions head.


Frequency Calm with Lion's ManeFrequency Cap’s CALM Mushroom Microdose Supplement with Lion’s Mane Fruiting Bodies Extract

Here at Frequency Caps, we grow our Lion’s Mane fruiting bodies out of hardwood sawdust and dowels   We also grow our mushrooms in an environment of healing sound energy. Acoustic designed rooms play recordings of crystal bowls-Tibetan monks chanting-scientific frequencies of all of the chakra energy centers-the angelic frequencies, etc. the Lion’s Mane fruiting body is used in our “calm” micro dose.  



Frequency Caps Energy with Lion's Mane
Frequency Caps Energy with Lion’s Mane

Frequency Cap’s ENERGY Mushroom Microdose Supplement with Lion’s Mane Mycellium Extract

Then there’s Lion’s Mane mycelium. Mycelium is what is grown underneath the Earth in top pinning mushrooms, or inside the wood in a decaying log (unseen by the human eye.) It is the brain of the organism. The mushroom itself is like an apple, it’s a fruit that pops up, leaving the “tree “if you will, unseen in the wood or under the ground.

When grown or cultivated, the Lion’s Mane mycelium is usually colonized in some type of grain bag. When Lion’s Mane mycelium is created in captivity, mycelium is injected into a liquid culture (usually sterilized oats to) colonize.

Lion’s Mane mycelium extract in powder form often is ground up Lion’s Mane mycelium that has colonized in the oats meaning you end up consuming the mycelium body with the oats that it was colonized in.

Here at Frequency, we used red Milo, which is a much higher quality cleaner, healthier grain than oats.

We grow the majority of our Lions Mane in-house, however we do out-source it with trusted vendors when we need to. All of our “Active” mushrooms strains are grown in-house with the strictest of measures and protocols in place.

Paul Stamets, one of the most famous self-taught mycologists in the world, came up with the Lions Mane mycelium Stamets stack, microdose formula. Which mainly includes Lions Mane mycelium and niacin.

Our “Energy” micro dose Frequency Caps use this recipe. 

1. Introduction 

  • What is Lion’s Mane Mushroom? 

           Lion’s Mane Mushroom, scientifically known as Hericium Erinaceus, is a unique fungus renowned for its shaggy, white tendrils that resemble a lion’s mane as it grows.

  • A brief overview of the mushroom and its historical use.

          This mushroom has been a staple in traditional Chinese medicine for centuries, revered for its potent health-promoting properties.

           Today, it’s classified as a supplement due to its dense concentration of bioactive compounds that can be isolated and ingested to potentially improve various aspects of human health.

  • The health benefits associated with its consumption.

          These benefits range from neuroprotective effects to immune system support, digestive health and anti-inflammatory properties, attracting considerable interest from the health and wellness community.

2. Historical Context 

  • Traditional Uses

Ancient cultures, particularly in Asia, have long utilized Lion’s Mane for its medicinal properties, often prescribing it for stomach ailments and to boost brain health. How ancient cultures utilized Lion’s Mane for medicinal and culinary purposes. It was also a gourmet food for the elite, with its seafood-like flavor making it a prized addition to traditional dishes.

3. Health Benefits

  • Brain Health

          Lion’s Mane is celebrated for its ability to promote nerve growth factor, which may aid in the maintenance and regeneration of neurons, thus supporting cognitive function and potentially mitigating the effects            of brain diseases.

  • Immune System Boost 

          The mushroom contains beta-glucans, which are known to modulate the immune system, enhancing the body’s defense against pathogens.

  • Digestive Health

           Its prebiotic fibers nourish beneficial gut bacteria, which is crucial for maintaining a healthy digestive system.

  • Anti-inflammatory Properties 

          Lion’s Mane exhibits anti-inflammatory effects that may alleviate symptoms of conditions like arthritis and may provide relief from muscle aches.

4. How to Consume Lion’s Mane Supplements 

  • Supplement Forms 

Lion’s Mane is available in various forms including capsules for convenience, powders for versatility in usage, tinctures for quick absorption, and teas for those who prefer a warm, soothing delivery method.

  • Dosage Recommendations

While there is no one-size-fits-all dosage, most supplements come with guidelines that suggest a starting point, which can be adjusted based on individual needs and responses.

5. Potential Side Effects

  • Common Side Effects 

While Lion’s Mane is generally considered safe, some individuals may experience gastrointestinal discomfort or allergic reactions. It’s important to monitor your body’s response and consult a healthcare provider if concerns arise.

  • Interactions with Other Medications 

As with any supplement, it’s crucial to be aware of potential interactions with other medications, particularly those that affect blood clotting or blood sugar levels.

6. How to Choose a Quality Supplement 

  • Labels and Certifications 

When selecting a Lion’s Mane supplement, look for clear labels detailing the ingredients, dosage, and ideally, certifications from third-party organizations that verify the product’s purity and potency.

  • Red Flags

Be wary of supplements that make exaggerated health claims, lack ingredient transparency, or do not provide information about third-party testing.

7. Conclusion 

  • The Future of Lion’s Mane 

As research continues to uncover the myriad benefits of Lion’s Mane, its popularity is likely to grow. Ongoing studies are exploring its potential in neurodegenerative disease treatment and general health maintenance, suggesting a bright future for this remarkable mushroom in the realm of supplements.

  • Personal Testimonials 

Mushroom Energy Microdose Products

“The Energy mushroom microdose has been the best medicine for my mental health. I can focus, be creative and relaxed all at once! I never thought this was possible… until I discovered Frequency. Thank you for your incredible products!” – Tara M.

“I was really at the end of my rope. The combination of Covid fatigue and having been cooped up for so long, left me feeling like I had no motivation and a huge difficulty with focusing. Since I started Frequency’s products, I have really seen a big difference in my overall sense of joy. My focus is there and my outlook is positive.” ~ Anonymous

Mushroom Calm Microdose Products

“I love the Calm microdose capsules. I have pretty crippling, generalized anxiety and it has made a huge difference in my daily functioning and life. I’m so happy about it because I’ve everything and nothing has seemed to work until now.” – Brian R.

“I have to say that the results from these products have been quite remarkable. Very hard to explain but I honestly feel like a different person; Something to do with being able to look forward and not backward to my old ways…” ~ Laura S

Infini-Tea Product

“Drinking my tea for the first time and it is so wonderful. It is delicious (and I’m a complete tea snob). I can feel the love, joy and peace that was given to the plants when they were grown and I am SO grateful to have found Frequency!” – Richard S.

Social Candy Caps Product

“The Candy Caps have been a total game changer for me. I have suffered from debilitating social anxiety for most of my life and have often used alcohol to help calm my nerves in a social environment. Ever since using Frequency’s products, I’ve felt more comfortable in my own skin…” – Will M.

“The combination of my morning microdose routine and having fun at night with the candy, has changed my life completely. I am no longer on my antidepressants and I even quit drinking!  It has taken away my worry and problems from my drinking and I have managed to create a new life! I highly recommend this combo – especially for the price –  compared to what I was doing!” – Melissa R.

Frequency Fudge Product

“The Frequency mushroom fudge is super tasty, and the perfect dose to complement any social setting. I found myself not wanting to smoke or drink. We danced all night and I had long, deep, meaningful conversations. I got closer with my friends instead of getting disconnected from them :-)” – Harry W.

8. Frequently Asked Questions (FAQs) 

  • What is Lion’s Mane Mushroom? 

Lion’s Mane Mushroom (Hericium erinaceus) is a type of medicinal mushroom known for its unique appearance and potential health benefits, especially for brain and nerve health.

  • What are the benefits of taking Lion’s Mane supplements? 

The benefits of taking Lion’s Mane supplements include support for cognitive function, potential nerve regeneration, immune system enhancement, anti-inflammatory effects, and digestive health support.

  • How does Lion’s Mane support brain health? 

Lion’s Mane contains compounds that can stimulate the production of nerve growth factor (NGF), which is essential for the growth and survival of neurons, potentially aiding in cognitive function and brain health.

  • Can Lion’s Mane Mushroom improve memory? 

Some studies suggest that Lion’s Mane may improve memory and concentration, although more research is needed to fully understand its effects on memory.

  • Is Lion’s Mane safe to take? 

Lion’s Mane is generally considered safe for most people when taken in recommended doses. However, as with any supplement, it is best to consult with a healthcare provider before starting.

  • Are there any side effects of Lion’s Mane Mushroom?

Some people may experience mild digestive upset or allergic reactions. If you experience any adverse effects, it’s recommended to stop use and consult a healthcare provider.

  • How should I take Lion’s Mane supplements? 

Lion’s Mane can be taken in various forms such as capsules, powders, tinctures, or teas. Follow the manufacturer’s instructions on dosage, or consult with a healthcare provider.

  • Can I take Lion’s Mane with other medications? 

If you are taking other medications, especially those that affect blood clotting or blood sugar levels, you should consult with a healthcare provider due to potential interactions.

  • How long does it take to feel the effects of Lion’s Mane? 

The time it takes to feel the effects can vary from person to person. Some may notice benefits within a few days, while for others, it may take several weeks.

  • Can pregnant or nursing women take Lion’s Mane supplements? 

There is limited research on the use of Lion’s Mane during pregnancy or breastfeeding. It is best to consult with a healthcare provider before use.

  • What should I look for when choosing a Lion’s Mane supplement? 

Look for supplements with clear labeling of ingredients, dosage, and ideally, third-party testing. Avoid products with vague ingredient lists or unsupported health claims.

  • Does Lion’s Mane contain any allergens? 

  • Lion’s Mane is a mushroom, so those with allergies to fungi should avoid it. Always check the label for additional allergens that may be included in the supplement formulation.
  • Can children take Lion’s Mane supplements?  

The safety and efficacy of Lion’s Mane supplements in children have not been well-studied. Consult with a pediatrician before giving Lion’s Mane to a child.

  • Can Lion’s Mane be used to treat medical conditions? 

While Lion’s Mane has been associated with various health benefits, it should not be used as a replacement for medical treatment. Always consult with a healthcare provider for medical advice.

Remember, while these answers are based on current knowledge and research, it’s always important to consult with a healthcare professional for personalized advice and information.

9. References 

This study investigates the neurotrophic effects of the Lion’s Mane mushroom, particularly its ability to stimulate the synthesis of nerve growth factor (NGF) in nerve cells. The research conducted in Malaysia found that compounds known as hericenones and erinacines in Hericium erinaceus could induce NGF synthesis. The study evaluated the synergistic effects of the mushroom’s aqueous extract with exogenous NGF on neurite outgrowth in neuroblastoma-glioma cells. The results showed that the combination of NGF and the mushroom extract significantly increased neurite outgrowth. However, the extract did not protect the cells from oxidative stress. In summary, the aqueous extract of H. erinaceus contains compounds that promote NGF synthesis and neurite outgrowth, but it does not have neuroprotective properties against oxidative stress. This study investigates the neurotrophic effects of the Lion’s Mane mushroom, particularly its ability to stimulate the synthesis of nerve growth factor (NGF) in nerve cells. The research conducted in Malaysia found that compounds known as hericenones and erinacines in Hericium erinaceus could induce NGF synthesis. The study evaluated the synergistic effects of the mushroom’s aqueous extract with exogenous NGF on neurite outgrowth in neuroblastoma-glioma cells. The results showed that the combination of NGF and the mushroom extract significantly increased neurite outgrowth. However, the extract did not protect the cells from oxidative stress. In summary, the aqueous extract of H. erinaceus contains compounds that promote NGF synthesis and neurite outgrowth, but it does not have neuroprotective properties against oxidative stress.

  • 9 Health Benefits of Lion’s Mane Mushroom 

The article from Healthline, authored by Erica Julson, MS, RDN, CLT, provides a comprehensive look at the potential health benefits of Lion’s Mane mushroom (Hericium erinaceus). The mushroom is noted for its unique, shaggy appearance resembling a lion’s mane and is used both culinarily and medicinally in Asian countries. The article outlines nine key benefits:

Potential Protection Against Dementia: Lion’s Mane contains compounds that may stimulate brain cell growth and protect against Alzheimer’s disease.

Relief from Mild Symptoms of Depression and Anxiety: The mushroom’s anti-inflammatory effects could reduce symptoms of anxiety and depression.

Nervous System Recovery: It may speed recovery from nervous system injuries by promoting the growth and repair of nerve cells.

Digestive Tract Protection: Lion’s Mane can protect against ulcers in the digestive tract by inhibiting growth of H. pylori and protecting the stomach lining.

Heart Disease Risk Reduction: The mushroom may improve fat metabolism and lower triglycerides, which are risk factors for heart disease.

Diabetes Management: It can help lower blood sugar levels and reduce diabetic nerve pain.

Cancer Fighting Potential: Lion’s Mane has been shown to kill cancer cells and slow tumor spread in animal and test-tube studies.

Anti-Inflammatory and Antioxidant Effects: The mushroom contains compounds that may reduce inflammation and oxidative stress.

Immune System Boost: It can boost immunity by increasing the activity of the intestinal immune system.

The article also discusses the various ways Lion’s Mane can be consumed, including raw, cooked, dried, or as tea, and its availability in supplement forms like tablets, capsules, powders, and tinctures. While generally considered safe, the article advises consulting with a doctor for proper dosage and notes that individuals with mushroom allergies should avoid Lion’s Mane.

In summary, Lion’s Mane mushroom is a promising natural supplement with a range of potential health benefits, particularly for brain and digestive health. However, the article emphasizes the need for more human studies to confirm these benefits.

  • Health Benefits Of Lion’s Mane 

The Forbes Health article by Nancy Lovering provides an in-depth look at the Lion’s Mane mushroom, highlighting its historical use in traditional Chinese medicine and its numerous potential health benefits. The mushroom is known for its neurotrophic properties, which may protect nerves from disease or decline and has been linked to various health-promoting benefits such as regulating blood sugar, reducing high blood pressure, promoting healthy energy levels, and combating fatigue. It also has potential roles in protecting heart, liver, and kidney health.

Lion’s Mane has been suggested as a potential alternative treatment for depression, with research indicating it may help ensure the presence of sufficient neurotransmitters, reduce nerve growth loss due to stress, and minimize inflammation associated with depression. The mushroom’s impact on nerve growth factor levels also suggests it could protect against cognitive disorders like Alzheimer’s disease.

The article also touches on Lion’s Mane’s potential in promoting recovery from brain injuries, reducing anxiety and stress, and supporting gastrointestinal health by inhibiting ulcer formation. While generally well-tolerated, some common side effects include gastrointestinal discomfort, nausea, and skin rash, with more serious allergic reactions being rare.

When it comes to usage, Lion’s Mane can be consumed as a supplement in capsules or powder form, or used fresh in culinary applications. Dosage recommendations vary, with some studies using about 1 gram of dried mushroom three times daily. However, it’s important to consult with a healthcare provider for proper dosage, especially during pregnancy and lactation due to insufficient research on its safety.

The article advises careful consideration when purchasing Lion’s Mane supplements, recommending professional-grade supplements that undergo third-party testing to ensure quality and efficacy.

  • Hericium erinaceus: an edible mushroom with medicinal values  

The article from PubMed discusses the nutritional and medicinal properties of Hericium erinaceus, commonly known as Lion’s Mane Mushroom. It is recognized for its long history in traditional Chinese medicine and is rich in β-glucan polysaccharides, which contribute to its anti-cancer, immuno-modulating, hypolipidemic, antioxidant, and neuro-protective activities. The mushroom is also reported to have anti-microbial, anti-hypertensive, anti-diabetic, and wound healing properties, among other therapeutic potentials. This review article consolidates recent advances in research on H. erinaceus, highlighting the mushroom’s health beneficial activities and identifying the bioactive compounds responsible for these medicinal properties.

  • Hericium erinaceus 

Hericium erinaceus, commonly known as Lion’s Mane mushroom, is a medicinal mushroom with a variety of health benefits, particularly known for its use in traditional Chinese medicine to treat digestive disorders. The mushroom contains several bioactive compounds, including polysaccharides, hericenones, and erinacines, which contribute to its health-promoting properties.

Research has shown that Hericium erinaceus has potential therapeutic applications, such as antitumor and immunomodulatory effects, neuroprotection and neuroregeneration, anti-gastric ulcer effects, antioxidation, hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, and anti-aging benefits. Its polysaccharides, in particular, have been studied for their antioxidant and anticancer properties. Studies have indicated that these polysaccharides can have anti-cancer activities against gastric and liver cancer, and there is ongoing research into their effects on colon cancer.

The mushroom is also associated with the synthesis of nerve growth factor, which is crucial for the maintenance and growth of certain neurons, suggesting a potential role in the treatment of neurological diseases. Additionally, Hericium erinaceus is used in the production of nutraceuticals—products derived from food sources with extra health benefits in addition to their basic nutritional value.

The mushroom’s increasing popularity in the health and wellness industry is reflected in the growing market for medicinal mushroom products, which includes a variety of preparations such as tablets, capsules, and extracts.

For further reading and exploration, you might consider looking into the following topics:

The specific mechanisms by which Hericium erinaceus exerts its neuroprotective effects.

The role of mushroom-derived compounds in cancer therapy and how they compare to traditional chemotherapeutic agents.

The potential for integrating Hericium erinaceus into conventional treatment regimens for digestive disorders.

  • Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers 

The study titled “Adults who microdose psychedelics report health-related motivations and lower levels of anxiety and depression compared to non-microdosers” investigates the practice of microdosing psychedelic substances, particularly focusing on the motivations, mental health, and demographics of individuals who microdose compared to those who do not.

The research involved a sample of 4050 self-selected microdosers and 4653 non-microdosers, using a mobile application for data collection. Psilocybin was the most commonly used substance for microdosing, and the study found diverse practices in terms of dosage, frequency, and the combination of psilocybin with non-psychedelic substances (a practice known as “stacking”).

Key findings include:

Microdosers were more likely to report a history of mental health concerns.

Among those with mental health concerns, microdosers exhibited lower levels of depression, anxiety, and stress across genders.

The primary motivation for microdosing was related to health and wellness, especially among females and individuals with mental health concerns.

The study suggests that microdosers perceive mental health benefits from their practice and underscores the need for further research into the mental health consequences of microdosing, including longitudinal studies.

  • Lion’s Mane Mushroom – Uses, Side Effects, and More 

The WebMD article provides an overview of Lion’s Mane Mushroom (Hericium erinaceus), a fungus that grows on dead hardwood trees like oak and is used in East Asian medicine. The mushroom is believed to improve nerve development and function and may protect nerves from damage. It is also thought to help protect the stomach lining. Lion’s Mane is used for various conditions including Alzheimer’s disease, dementia, and stomach problems, but there is no strong scientific evidence to support these uses.

The article does not list specific side effects, precautions, interactions, or dosing information, which suggests that while Lion’s Mane is of interest for its potential health benefits, more research is needed to fully understand its effects and proper usage. It emphasizes the importance of consulting healthcare providers for advice tailored to individual health circumstances.

The article on Medical News Today, authored by Jayne Leonard and reviewed by the MNT medical review team, discusses the potential health benefits and side effects of Lion’s Mane mushrooms (Hericium erinaceus). These mushrooms are noted for their unique appearance and have been used in Asia for culinary and medicinal purposes. The article outlines several potential health benefits based on research, including:

Inflammation and Oxidation: Lion’s Mane has high antioxidant activity, which may help fight inflammation and oxidation in the body, contributing to various medical conditions.

Immune Function: Studies suggest that Lion’s Mane can enhance the immune system by reducing inflammation and preventing oxidation, and may boost the activity of the intestinal immune system.

Anxiety and Depression: Extracts from the mushroom may help treat anxiety and depression, as indicated by animal studies and a small human study where participants reported lower levels of irritation and anxiety.

Cognitive Health: There is potential for Lion’s Mane to boost cognitive function, with animal studies showing improved recognition memory. It may also have the potential to treat or prevent diseases that cause cognitive decline.

Heart Health: Animal studies suggest that Lion’s Mane extract may have a cholesterol-lowering effect.

Cancer: The mushroom has shown therapeutic potential against human leukemia and may fight liver, colon, and gastric cancer cells in animal models.

Diabetes: Lion’s Mane mushroom extract has been shown to lower blood sugar levels in diabetic rats and may help manage nerve damage resulting from high blood sugar.

Digestive Health: The mushroom may fight inflammation, which could be beneficial for inflammatory bowel disease, and may also boost immune function and encourage the growth of good gut bacteria.

Wound Healing: Topical application of Lion’s Mane extract may accelerate the healing of skin wounds in rats.

Nervous System Recovery: Extracts may encourage nerve cells to grow and repair more quickly, as shown in a study where rats with nerve damage had quicker nerve regeneration.

The article also notes that while Lion’s Mane mushrooms appear to be safe to eat in moderate quantities, the safety and effectiveness of supplements are less clear due to less stringent regulations. It advises that people should follow the dosages on supplement labels carefully and consult a doctor before use. There are no known side effects, and the mushrooms should be safe for most people to eat in moderation.

  • The Ultimate Guide To Lion’s Mane Mushrooms 

The article on MyTwentyTwo serves as a comprehensive guide to Lion’s Mane mushrooms, detailing their benefits, usage, and what makes them unique. Lion’s Mane mushrooms are distinguished from other fungi by their significant health benefits, which include improved brain function, mental health, immunity, and reduced inflammation. They have been a part of traditional Asian medicine for centuries.

Lion’s Mane mushrooms are characterized by their white, spiny appearance, resembling a pom-pom or a lion’s mane. They grow on hardwood trees in woodlands across North America, Europe, and Asia, particularly on beech and oak trees. Unlike psychedelic mushrooms, Lion’s Mane mushrooms are not hallucinogenic but are considered a functional food due to their health benefits.

The article explains that Lion’s Mane mushrooms contain compounds that stimulate the production of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are crucial for brain health. They also contain beta-glucans and prebiotics that boost the immune system, as well as antioxidants and polysaccharides with various health properties.

The benefits of Lion’s Mane mushrooms are numerous. They can improve and protect brain health, boost focus and performance, reduce inflammation and oxidation, improve mental health, anxiety, and mood, and strengthen the immune system. The article suggests that incorporating Lion’s Mane mushrooms into one’s diet can be done through various recipes or supplements, emphasizing the importance of quality in choosing supplements.

The guide also provides links to further reading on the subject, including articles on the power of the mushroom network and the potential of Lion’s Mane mushrooms to aid in the recovery from long COVID.

  • Stamets Stack (Stacking Lion’s Mane and Psilocybin Mushrooms) 

The Microdosing Institute provides an in-depth look at the Stamets Stack, a microdosing protocol developed by mycologist Paul Stamets. This method involves stacking Lion’s Mane mushroom with niacin (vitamin B3) and psilocybin, the active compound in magic mushrooms. The combination is believed to enhance neurogenesis, create new neural pathways, and repair neurological damage.

Lion’s Mane is praised for its nerve-regenerative properties and has been used in traditional Chinese and Japanese medicine. It stimulates the production of Nerve Growth Factors (NGF), which are essential for neuron growth and maintenance. Research suggests that Lion’s Mane can reverse the effects of neurotoxins in mice and may support brain health in aging humans.

Niacin is included in the stack for its vasodilating effects, which may help deliver the psilocybin and Lion’s Mane more effectively into the brain. However, high doses of niacin can cause a “flush,” a harmless but uncomfortable sensation. The protocol suggests a microdosing cycle of four days on, followed by three days off, with a reset after four weeks.

The article emphasizes the importance of consulting a healthcare professional before starting the Stamets Stack, especially for individuals with certain health conditions. It also recommends starting with a lower dose to find the optimal amount for microdosing and to avoid potential tolerance build-up.

  • The Stamets Stack: Should You Try Microdosing? 

The article discusses the concept of microdosing, particularly focusing on a protocol introduced by Paul Stamets, a renowned mycologist. Microdosing involves taking very low doses of psychedelic substances, such as psilocybin mushrooms, to enhance cognitive function without the hallucinogenic effects. Stamets’ protocol, known as the Stamets Stack, combines psilocybin, Lion’s mane mushrooms, and niacin with the aim of improving brain health and cognition.

The article notes that while psilocybin is illegal in many countries, there is growing interest in its potential therapeutic benefits, particularly for mood and substance use disorders. Paul Stamets is highlighted as a leading figure in the field of mycology, with significant contributions to the understanding of fungi and their potential uses in health and ecology.

Microdosing is described as taking sub-hallucinogenic doses of psychedelic substances to achieve benefits such as reduced depression and anxiety, improved focus, and increased creativity. However, the article emphasizes that there is still limited definitive evidence for the effectiveness and safety of psychedelic microdosing.

The Stamets Stack is thought to enhance neuroregeneration and cognition, with each component playing a specific role. Lion’s mane is noted for its neurogenerative properties, while niacin helps distribute the active substances across the blood-brain barrier and acts as an anti-abuse agent.

The article also touches on the legal and health considerations of microdosing, advising caution and consultation with a healthcare provider before starting any such regimen. It concludes by mentioning the microdosing protocol suggested by Stamets, which involves a cycle of dosing and breaks to prevent tolerance build-up.

  • Lion’s mane mushroom improves memory and nerve growth 

Researchers at the University of Queensland have discovered active compounds in the Lion’s Mane mushroom (Hericium erinaceus) that can stimulate brain cell growth and enhance memory. Professor Frederic Meunier from the Queensland Brain Institute indicated that these findings come from pre-clinical trials, where extracts from the Lion’s Mane mushroom showed a significant impact on the growth of brain cells and memory improvement.

The laboratory tests involved measuring the effects of compounds isolated from Hericium erinaceus on cultured brain cells. The results were promising, showing that these compounds promote the extension of neuron projections, which are essential for forming connections with other neurons in the brain. Using advanced microscopy techniques, the team observed that the mushroom extract and its active components substantially increased the size of growth cones, critical for brain cells to connect and establish new neural pathways.

This breakthrough has potential implications for treating and protecting against neurodegenerative cognitive disorders, such as Alzheimer’s disease. Dr. Ramon Martinez-Marmol, co-author of the study, suggests that these bioactive compounds could lead to improved memory formation. Dr. Dae Hee Lee from CNGBio Co, a collaborator on the research project, emphasizes the significance of understanding the molecular mechanisms of Lion’s Mane mushroom compounds and their impact on brain function, particularly memory.

  • Psilocybin and Lion’s Mane: Healthy brain 

The article explores the potential cognitive benefits of combining psilocybin, Lion’s Mane mushrooms, and niacin, following a formula proposed by mycologist Paul Stamets. The article begins by discussing the importance of directing the flow of thoughts and feelings for a healthy brain, noting the role of environmental pollution in neurological decline.

Paul Stamets, an experienced mycologist, is introduced as a researcher into the medicinal properties of mushrooms and their role in environmental cleanup, a process called mycoremediation. The article emphasizes the potential of mushrooms to remove toxic substances from the environment and their composting abilities.

The focus then shifts to the medicinal effects of mushrooms, particularly Lion’s Mane, which has been used for centuries to stimulate and strengthen the brain. Scientific research supports its ability to produce ‘Nerve Growth Factor’ (NGF), which helps slow down the aging of neurons in the brain and is beneficial for cognitive functions.

The article describes Stamets’ formula for a healthy brain, which combines Lion’s Mane, microdosing of psilocybin, and niacin (vitamin B3). This combination is suggested to help the brain form new connections, improve mental clarity, and foster creativity. The protocol recommends a cycle of dosing and breaks to prevent tolerance build-up.

Lion’s Mane is highlighted for its cognitive enhancement properties, while psilocybin, in microdoses, is presented as a subtle way to gain insights into behavior without the overwhelming effects of a full psychedelic experience. Niacin is mentioned for its role in cell renewal, metabolism, and facilitating the effects of Lion’s Mane and psilocybin.

The article suggests that the combination of these three components could improve memory, intelligence, vision, athleticism, reaction time, balance, mindset, vitality, and mental health. It concludes by encouraging readers to try the formula and monitor their experiences closely.

  • How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more 

The article from WCVB discusses the potential of psilocybin, the psychedelic compound found in mushrooms, to treat mental health conditions like depression and anxiety. Here’s a summary of the key points:

Research on Psilocybin: Recent studies have shown that psilocybin can lead to significant improvements in mental health. The substance appears to “rewire” the brain, creating new connections across different regions. This rewiring can potentially alleviate symptoms of depression and anxiety.

FDA Designation: The U.S. Food and Drug Administration (FDA) has designated psilocybin as a “breakthrough therapy” for depression, which expedites the development and review of drugs that show substantial improvement over existing treatments.

Mechanism of Action: Psilocybin is believed to work by binding to serotonin receptors in the brain, which can lead to altered consciousness and perception. The resulting changes in brain connectivity might be responsible for the therapeutic effects.

Clinical Trials: Clinical trials have reported that a single dose of psilocybin, in conjunction with therapy, produced rapid and large reductions in symptoms of depression and anxiety. These effects were sustained for weeks or even months after treatment.

Expert Opinions: Experts in the field suggest that psilocybin therapy could represent a significant shift in the treatment of mental health disorders. However, they also caution that more research is needed to understand the long-term effects and safety.

Legal Status and Access: Psilocybin remains a Schedule I controlled substance in the United States, which means it’s illegal for recreational use and has no recognized medical use. However, some cities and states are beginning to change their laws regarding psychedelics, reflecting a growing interest in their therapeutic potential.

The article underscores the promising nature of psilocybin as a treatment for mental health conditions, while also highlighting the need for further research and consideration of legal and safety aspects.

  • Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin  

The patent US20180021326A1 discusses methods and compositions for enhancing neurogenesis, resolving neuropathy, and improving neurological health using fungal extracts and their active ingredients. The primary focus is on the use of psilocybin and psilocin, found in Psilocybe mushrooms, combined with erinacines and hericenones from Hericium mushrooms, and enhanced with niacin (vitamin B3). This combination is believed to aid in repairing and improving neurological functioning and signaling.

The patent suggests that this unique blend not only activates neurogenesis but may also help mitigate or reverse nerve degeneration, including ocular and cochlear nerve damage. Niacin, in particular, is highlighted for its neural anti-inflammatory properties and its ability to enhance the neurogenic effects of the other ingredients by facilitating their crossing of the blood-brain barrier and improving blood flow in the brain.

The patent also outlines various formulations with different concentrations of the active ingredients, designed to cater to different therapeutic needs and to prevent potential abuse by inducing discomfort when taken in excessive amounts.

The invention is seen as potentially beneficial not only for those suffering from neurological disorders but also for healthy individuals seeking to improve cognitive function, memory, intelligence, and overall mental health.

  • Are Lion’s Mane Mushrooms Psychedelic?  

Lion’s Mane mushrooms are gaining popularity for their positive effects on mental and physical health. They are not psychedelic and do not cause hallucinations or alter perception. Instead, they are adaptogens that help manage stress and improve mood and cognitive health without hallucinogenic effects. Lion’s Mane contains compounds like erinacines and hericenones, which stimulate nerve growth factors, and polysaccharides like beta-glucans, which support the immune system and overall health. While generally safe, Lion’s Mane can cause digestive discomfort in some and may interact with certain medications. The mushroom has been traditionally used in Chinese medicine and is now recognized for its potential to enhance brain function, support the immune system, and improve mental health. For daily consumption, high-quality Lion’s Mane extracts are recommended, ensuring you get the benefits without the hassle of cooking the mushroom, which can degrade some beneficial compounds.

  • Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

The article titled “Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study” published in Translational Psychiatry explores the effects of microdosing psilocybin mushrooms, which has gained popularity for purported benefits on creativity, cognitive function, and mental health. The study involved 34 participants who were given either 0.5 g of dried Psilocybe cubensis mushrooms or a placebo in a double-blind setting. The researchers assessed the effects on subjective experience, behavior, creativity, perception, cognition, and brain activity using EEG.

Key findings include:

Participants reported significantly more intense acute effects with the active dose compared to the placebo, but only if they correctly identified their experimental condition.There were changes in EEG power in the theta band and preserved levels of signal complexity, but no evidence of enhanced well-being, creativity, or cognitive function. The study suggests that some benefits of microdosing may be due to the expectation of positive effects rather than the pharmacological action of the mushrooms.

The study concludes that while low doses of psilocybin mushrooms can result in noticeable subjective effects and altered EEG rhythms, there is no strong evidence to support the claimed benefits on creativity and cognitive functions.

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